About HR+/HER2– breast cancer
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What is HR+/HER2– breast cancer?
HR+ breast cancer means the cancer cells use the body’s hormones (estrogen and progesterone) to help them grow. HER2- means the breast cancer has low levels of the HER2 protein. These cancers usually grow and spread more slowly than HER2+ breast cancers.
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How common is HR+/HER2– breast cancer?HR+/HER2– breast cancers make up nearly 70% of all breast cancers.
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What are the symptoms of HR+/HER2– breast cancer?Symptoms of HR+/HER2– breast cancer may include changes in breast size, a lump or hardened area near the breast or armpit, skin changes affecting the breast or nipple, nipple discharge, and a nipple that pulls inward. Be sure to talk to your doctor about any symptoms you may be experiencing.
About DATROWAY
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What is DATROWAY?DATROWAY is a type of treatment called an antibody-drug conjugate, or ADC. It is approved for adults who have HR+/HER2– breast cancer that is unresectable or metastatic, and have received prior endocrine-based therapy and chemotherapy for unresectable or metastatic disease. DATROWAY is designed to identify cancer cells that have Trop-2 (pronounced trohp-too), a protein found on the surface of cancer cells. Visit How DATROWAY May Work to learn more.
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When was DATROWAY approved by the FDA?DATROWAY was approved by the FDA in January 2025 for adults who have HR+/HER2– breast cancer that is unresectable or metastatic, and have received prior endocrine-based therapy and chemotherapy for unresectable or metastatic disease.
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How was DATROWAY studied?DATROWAY was studied in a clinical trial. Visit Results With DATROWAY to learn more about the study and its results.
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What are the side effects of DATROWAY?DATROWAY can cause serious side effects, including lung problems that may be severe, life-threatening, or may lead to death, eye problems, mouth ulcers and sores, and harm to your unborn baby. To learn more about these serious side effects as well as common side effects, visit Possible Side Effects. For tips about how to manage certain side effects, visit Managing Side Effects. Talk to your doctor about any side effects you may be experiencing.
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What can I do that may help me with certain side effects?
There are steps you can take that may help manage certain side effects. Consult your care team and refer to Managing Side Effects to learn more.
There are also support options to help you access tools to manage side effects, such as recommended eye drops and mouthwash, and a Starter Kit for starting DATROWAY treatment. Visit Savings or ask your doctor to learn more.
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How does DATROWAY work?DATROWAY is a type of treatment known as an antibody-drug conjugate (ADC). It is designed to identify breast cancer cells that have Trop-2 (pronounced trohp-too), a protein found on the surface of cancer cells. DATROWAY is thought to work by finding breast cancer cells, entering them, and then releasing medicine into them that helps destroy them. Although DATROWAY is designed to target breast cancer cells, it may also affect some healthy cells. This treatment may not work for everyone. To learn more, visit How DATROWAY May Work.
Dosing information
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How is DATROWAY given?DATROWAY is given through an intravenous (IV) infusion at your doctor’s office or at your treatment center. Visit Dosing Information to learn more about how DATROWAY is administered.
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How often will I be given DATROWAY?DATROWAY is given once every 3 weeks (21-day cycle). Visit Dosing Information to learn more.
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What should I expect before my first DATROWAY infusion?Before your first infusion, you may be given medicines to help reduce nausea, vomiting, and infusion-related reactions. Visit Dosing Information to learn more about what to expect before your infusion.
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How long will my first DATROWAY infusion be?Your first IV infusion will take 90 minutes to complete. Once the infusion is finished, your care team will monitor you for at least 1 hour to see if you have any infusion-related reactions. Visit Dosing Information to learn more about what to expect at your first infusion.
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After my first infusion, how long will my future infusions be?If you do not have any infusion-related reactions after your first infusion, future infusions may take 30 minutes. You will be monitored for at least 1 hour after your second infusion and for at least 30 minutes after future infusions. Visit Dosing Information to learn more.
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What can I do before or during my infusions to help with certain side effects?During your infusion, holding ice chips or ice water in your mouth may help with mouth sores. There are also tools available to help you manage side effects before or during your infusions, such as recommended eye drops and mouthwash to use. Visit Managing Side Effects to learn more.
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What happens if I experience an infusion-related reaction or a side effect?Your doctor may slow down or temporarily stop your infusion of DATROWAY if you have an infusion-related reaction, or permanently stop DATROWAY if you have severe infusion reactions, including severe allergic reactions. If you experience any side effects, notify your care team right away. To learn more, visit Possible Side Effects.
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What if I miss an appointment or have to reschedule?If you miss a planned dose of DATROWAY, call your care team right away to schedule an appointment. Do not wait until the next planned treatment cycle.
DATROWAY support
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What are the financial support options available for DATROWAY?DATROWAY4U has programs that may help you access and afford your prescribed DATROWAY treatment, including benefit reviews, prior authorizations, claims appeals, and paying for your prescription. If you have commercial insurance, you may be eligible for the DATROWAY Patient Savings Program, which may help with out-of-pocket costs. See the Savings page to learn more.
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What other types of support and resources are available?The Starter Kit includes information about DATROWAY, oral care and eye drop vouchers, and other treatment resources. If you have a prescription for DATROWAY and have not received your kit, talk to your doctor. You can also visit Care Partner Support, Community Support, and the DATROWAY Getting Started Guide for additional resources.
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Are there any advocacy groups available for people on DATROWAY?Visit Community Support to explore available advocacy groups—they may provide resources and offer community throughout your treatment journey. Connecting with others going through similar experiences may be helpful for you or your care partner.
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My loved one is going through treatment. What can I do to best support them?Go to Care Partner Support for tips and information that may be helpful as you care for your loved one.