Frequently asked questions

Non-small cell lung cancer, or NSCLC, is the most common type of lung cancer, making up about 80% to 85% of all lung cancer cases.

Some people with NSCLC have mutations in their EGFR gene. EGFR stands for epidermal growth factor receptor. This gene makes the EGFR protein, which helps cells grow. A mutation in the EGFR gene can cause the cells to grow too much, which can cause cancer.

In the United States, EGFR mutations are present in about 10% to 15% of lung cancers.

DATROWAY is a type of treatment called an antibody-drug conjugate, or ADC. It was approved for adults with non-small cell lung cancer (NSCLC) that is locally advanced (has spread to areas outside of the lung) or metastatic (has spread to other parts of the body) that has certain mutations in a gene called epidermal growth factor receptor (EGFR) and who have received prior EGFR-based medicine and platinum-based chemotherapy.
DATROWAY was FDA-approved for this use based on clinical trials that measured how many patients responded and how long they responded. DATROWAY is still being studied to confirm these results. DATROWAY is designed to identify cancer cells that have Trop-2 (pronounced trohp-too), a protein found on the surface of cancer cells. Visit How DATROWAY May Work to learn more.

DATROWAY was approved by the FDA in June 2025 to treat adults with non-small cell lung cancer (NSCLC) that is locally advanced (has spread to areas outside of the lung) or metastatic (has spread to other parts of the body) that has certain mutations in a gene called epidermal growth factor receptor (EGFR) and who have received prior EGFR-based medicine and platinum-based chemotherapy. DATROWAY was FDA-approved for this use based on clinical trials that measured how many patients responded and how long they responded. DATROWAY is still being studied to confirm these results.

DATROWAY was studied in 2 clinical trials. Visit Results With DATROWAY to learn more about the studies and the results.

DATROWAY can cause serious side effects, including lung problems that may be severe, life-threatening, or may lead to death, eye problems, mouth ulcers and sores, and harm to your unborn baby. To learn more about these serious side effects as well as common side effects, visit Possible Side Effects. For tips about how to manage certain side effects, visit Managing Side Effects. Talk to your doctor about any side effects you may be experiencing.

There are steps you can take that may help manage certain side effects. Consult your care team and refer to Managing Side Effects to learn more.

There are also support options to help you access tools to manage side effects, such as recommended eye drops and mouthwash, and a Starter Kit for starting DATROWAY treatment. Visit Savings or ask your doctor to learn more.

DATROWAY is a type of treatment known as an antibody-drug conjugate (ADC). It is designed to identify cancer cells that have Trop-2 (pronounced trohp-too), a protein found on the surface of cancer cells. DATROWAY is thought to work by finding cancer cells, entering them, and then releasing medicine into them that helps destroy them. Although DATROWAY is designed to target cancer cells, it may also affect some healthy cells. This treatment may not work for everyone. To learn more, visit How DATROWAY May Work.

DATROWAY is given through an intravenous (IV) infusion at your doctor’s office or at your treatment center. Visit Dosing Information to learn more about how DATROWAY is administered.

DATROWAY is given once every 3 weeks (21-day cycle). Visit Dosing Information to learn more.

Before your first infusion, you may be given medicines to help reduce nausea, vomiting, and infusion-related reactions. Visit Dosing Information to learn more about what to expect before your infusion.

Your first IV infusion will take 90 minutes to complete. Once the infusion is finished, your care team will monitor you for at least 1 hour to see if you have any infusion-related reactions. Visit Dosing Information to learn more about what to expect at your first infusion.

If you do not have any infusion-related reactions after your first infusion, future infusions may take 30 minutes. You will be monitored for side effects for at least 1 hour after your second infusion and for at least 30 minutes after future infusions. Visit Dosing Information to learn more.

During your infusion, holding ice chips or ice water in your mouth may help with mouth sores. There are also tools available to help you manage side effects before or during your infusions, such as recommended eye drops and mouthwash to use. Visit Managing Side Effects to learn more.

Your doctor may slow down or temporarily stop your infusion of DATROWAY if you have an infusion-related reaction, or permanently stop DATROWAY if you have severe infusion reactions, including severe allergic reactions. If you experience any side effects, notify your care team right away. To learn more, visit Possible Side Effects.

If you miss a planned dose of DATROWAY, call your care team right away to schedule an appointment. Do not wait until the next planned treatment cycle.

DATROWAY4U has programs that may help you access and afford your prescribed DATROWAY treatment, including benefit reviews, prior authorizations, claims appeals, and paying for your prescription. If you have commercial insurance, you may be eligible for the DATROWAY Patient Savings Program, which may help with out-of-pocket costs. See the Savings page to learn more.

The Starter Kit includes information about DATROWAY, oral care and eye drop vouchers, and other treatment resources. If you have a prescription for DATROWAY and have not received your kit, talk to your doctor. You can also visit Care Partner Support, Community Support, and the DATROWAY Getting Started Guide for additional resources.

Visit Community Support to explore available advocacy groups—they may provide resources and offer community throughout your treatment journey. Connecting with others going through similar experiences may be helpful for you or your care partner.

Go to Care Partner Support for tips and information that may be helpful as you care for your loved one.